THE PRESENT INVENTION RELATES TO THE USE OF VEGF ANTAGONISTS AND A NOVEL ANTI-α5β1 ANTIBODY FOR TREATING CANCER AND INHIBITING ANGIOGENESIS AND/OR VASCULAR PERMABILITY, INCLUDING INHIBITING ABNORMAL ANGIOGENESIS IN DISEASES. THE PRESENT INVENTION ALSO RELATES TO COMPOSITIONS AND KITS COMPRISING NOVEL ANTI-α5β1 ANTIBODIES AND METHODS OF MAKING AND USING THEM. FIG. NO. 11