SUNG JEAN C,MANZANEDO DIANA,PERRY JASON M,DEHAAN WESLEY H,TRAUTMAN BRIAN
申请号：
IN8943/DELNP/2015
公开号：
IN2015DN08943A
申请日:
2015.09.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to respirable dry powder comprising respirable dry particles that comprise sodium chloride leucine and tiotropium bromide wherein the sodium chloride is about 60% to about 90% the leucine is about 10% to about 40% the tiotropium bromide is about 0.01% to about 0.5% and optionally one or more additional therapeutic agents up to about 20% wherein all percentages are weight percentages on a dry basis and all the components of the respirable dry particles amount to 100%. The invention also relates to respirable dry powders that contain respirable dry particles that comprise sodium chloride leucine and tiotropium bromide wherein the sodium chloride is 67% to 84% the leucine is 12% to 28% the tiotropium bromide is about 0.01% to about 0.5% and optionally one or more additional therapeutic agents up to about 20% wherein all percentages are weight percentages on a dry basis and all the components of the respirable dry particles amount to 100%. The invention also relates to respirable dry powders that contain respirable dry particles that comprise about 79.5% to about 80.5% (w/w) sodium chloride about 19.5% to about 20.5% (w/w) leucine and about 0.01% to about 0.5% (w/w) tiotropium bromide and methods for treating a subject using the respirable dry powders.
