Kathryn Prickett;Will Vine;Nigel R.A. Beeley;Andrew A. Young
发明人:
Andrew A. Young,Will Vine,Kathryn Prickett,Nigel R.A. Beeley
申请号：
US13080051
公开号：
US08759291B2
申请日:
2011.04.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
