TENG, CHE MING,邓哲明,鄧哲明,KUO, SHENG CHU,郭盛助,LEE, FANG YU,李芳裕,PAN, SHIOW LIN,潘秀玲,GUH, JIH HWA,顾记华,顧記華
申请号：
TW095117714
公开号：
TWI365742B
申请日:
2006.05.18
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
This invention relates to a method for treating cancer including administrating to a subject in need thereof an effective amount of a compound of the formula: wherein, A is H or each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl； each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR', (CH 2 ) m OR, (CH 2 ) m SR, (CH 2 ) m NRR' , (CH 2 ) m CN, (CH 2 ) m C(O)OR, (CH 2 ) m CHO, (CH 2 ) m CH=NOR, (CH 2 ) m C(O)N(OR)R', N(OR)R', or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are O(CH 2 ) m O, in which each of R and R', independently, is H or C 1 ~C 6 alkyl； and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.本發明涉及一種治療癌症的方法，該方法包括向有需要的受試者施用有效量的下式化合物：；其中，A是H或 ；Ar1、Ar2和Ar3每一者獨立為苯基、噻吩基、呋喃基、吡咯基、吡啶基或嘧啶基；R1、R2、R3、R4、R5和R6每一者獨立為R、硝基、鹵素、C(O)OR、C(O)SR、C(O)NRR’、(CH2)mOR、(CH2)mSR、(CH2)mNRR’、(CH2)mCN、(CH2)mC(O)OR、(CH2)mCHO、(CH2)mCH=NOR、(CH2)mC(O)N(OR)R’、N(OR)R’；或R1和R2一起、R3和R4一起、或R5和R6一起為O(CH2)mO，其中R和R’每一者獨立地為H或C1~C6烷基；並且m是0、1、2、3、4、5或6；而n是0、1、2或3。
