Methods are described for inducing cognition and motor function enhancement in patients suffering from Parkinson’s disease by administering an effective amount of an Adenosine 2a antagonist such as 4-hydroxy-4-methylpiperidine-1-carboxylic acid-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide (TOZADENANT, SYN115). The Adenosine 2a antagonist can optionally be administered in combination with a dopamine precursor, such as levodopa, or a dopamine receptor agonist.