The present invention provides the method that individual acute, Delayed onset or expected property vomiting are treated within sustained period, is related to a part of the intact skin of a composition application what individual, the composition includes: the 5-HT3 of i. antiemetic effective quantityReceptor antagonist； Ii. the penetration enhancers of the infiltration enhancing amount of 0.5 weight % of skin contacting adhesive layer to 15 weight % are accounted for； And iii. adhesive agent.本發明提供在持續時期內治療個體急性、遲發性或預期性嘔吐之方法，其涉及將一組合物應用於個體之完整皮膚之一部分，該組合物包含：i.止吐有效量之5－HT3受體拮抗劑；ii.占皮膚接觸層0.5重量%至15重量%之滲透增強量之滲透增強劑；及iii.黏著劑。
