COMPOSITIONS ET METHODES POUR LE TRAITEMENT D'UNE MALADIE INFLAMMATOIRE DE L'INTESTIN A L'AIDE D'UNE POLYTHERAPIE A BASE D'INHIBITEURS A PETITES MOLECULES DE RECEPTEUR 9 DE CHIMIOKINE C-C (CCR9) ET D'ANTICORPS BLOQUANTS ANTI-INTEGRINE ALPHA4BETA7

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专利权人:

INC.;CHEMOCENTRYX

发明人:

EBSWORTH, KAREN,WANG, YU,ZENG, YIBIN,ZHANG, PENGLIE,TAN, JOANNE

申请号：

CA2960876

公开号：

CA2960876A1

申请日:

2015.10.05

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-a4p7 integrin antibody such as vedolizumab. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-a4p7 integrin antibody.

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