A surgical staple cartridge for use with a surgical end effector that includes a lock member that is movable between a locked configuration wherein a firing member is prevented from axial travel through the surgical end effector and an unlocked configuration wherein the firing member is axially advanceable. The staple cartridge includes a cartridge body that supports a cam assembly therein that is movable between a starting position and an ending position. The cam assembly defines a central axis and includes at least one unlocking feature that is laterally offset from the central axis and is configured to engage the lock member when the cartridge body is seated within the end effector and the cam assembly is in said starting position to thereby move the lock member to the unlocked configuration.
