According to one embodiment, forming a custom medical mask includes, while an oral appliance is positioned in a users mouth to receive the users teeth and is coupled to an orientation device, applying an impression material over the device and the users face, such that the impression material conforms to the device and to the users unique facial features. The impression material may be removed together with the device and a cast may be created using the impression material together with the device as a mold, such that the cast conforms to the impression material and the device. A deformable material may be applied to the cast to form a custom medical mask for the user, such that the deformable material conforms to the cast. The custom medical mask is custom-fitted to the users unique facial features and custom-oriented to the users teeth.