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НАЦЕЛИВАНИЕ ФАКТОРОВ СВЕРТЫВАНИЯ КРОВИ НА РЕЦЕПТОР TLT-1 НА ПОВЕРХНОСТИ АКТИВИРОВАННЫХ ТРОМБОЦИТОВ
专利权人:
НОВО НОРДИСК А/С
发明人:
ХИЛЬДЕН Ида,ПЕШКЕ Бернд,БРАЙНХОЛЬТ Йенс,КОФОД-ХАНСЕН Микаэл
申请号:
RU2013142015
公开号:
RU2013142015A
申请日:
2012.03.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. procoagulant protein comprising (i) at least one blood coagulation factor, covalently attached to (ii) a monoclonal antibody or fragment thereof that are capable of binding specifically to (iii) TLT-1 and / or fragment thereof or variantom.2. Procoagulant protein of claim 1, wherein component (i) is a serine protease or its proizvodnym.3. Procoagulant protein of claim 2, wherein the component (i) is a polypeptide factor FVII.4. Procoagulant protein of claim 2, wherein the component (i) is a polypeptide factor FIX.5. Procoagulant protein of claim 1, wherein component (ii) is a fragment Fab.6. Procoagulant protein of claim 1, wherein the epitope for the component (ii) comprises one or more residues selected from the group consisting of V17, Q18, S19, H20, Y21, R22, L23, Q24, D25, V26, K27, A28 , L63, G64, G65, G66, L67, L68, G89, A90, R91, G92, P93, Q94, I95 and L96 from the sequence SEQ ID NO: 5.7. Procoagulant protein of claim 1, wherein the epitope for the component (ii) comprises one or more residues selected from the group consisting of L36, P37, E38, G39, C40, Q41, P42, L43, V44, S45, S46, A47 , V73, T74, L75, Q76, E77, e78, D79, A80, G81, E82, Y83, G84, C85, M86, R91, G92, P93, Q94, I95, L96, N97, R98, V99, S100 and L101 sequence of SEQ ID NO: 5.8. Procoagulant protein of claim 1, wherein the epitope for the component (ii) comprises one or more residues selected from the group consisting of V17, Q18, S19, H20, Y21, R22, L23, Q24, D25, V26, K27, A28 , R91, G92, P93, Q94, I95, L96, N97, R98, V99, S100 and L101 of the sequence SEQ ID NO: 5.9. Procoagulant protein of claim 1, wherein the epitope for the component (ii) comprises one or more residues selected from the group consisting of K118, I119, G120, S121, L122, A123, E124, N125 and A126, F127 sequence of SEQ ID NO: 6.10. Procoagulant protein of claim 1, wherein the epitope for the component (ii) contains one yl1. Прокоагулирующий белок, содержащий (i) по меньшей мере один фактор свертывания крови, ковалентно
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