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СИСТЕМЫ ДОСТАВКИ ЛЕКАРСТВ
专利权人:
БИОКОМПАТИБЛС ЮКЕЙ ЛИМИТЕД (GB)
发明人:
АШРАФИ Курош (GB),ЛЬЮИС Эндрю Леннард (GB),ХЕЙСМЭН Клэр (GB),ЛЛОЙД Эндрю (GB),ФИЛИПС Гари (GB)
申请号:
RU2013135454/15
公开号:
RU2013135454A
申请日:
2012.01.27
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Microparticles comprising a gel structure which comprises a synthetic polymer and a drug, wherein said microparticles have an average diameter in the range of 40 to 1500 microns, and the polymer is crosslinked groups containing disulfide bonds, and is in the form gidrogelya.2. Microparticles according to Claim. 1 for use in a method of treatment embolization comprising lekarstva.3 release step. Microparticles according to claim. 2, characterized in that when used in a method of embolization therapy exposed hypoxic environment in which disulfide bonds are cleaved, which facilitates release lekarstva.4. Microparticles according to claim. 2, characterized in that it can be applied in a method of treatment embolization, which is a method of treating opuholi.5. Microparticles according to claim. 3, characterized in that it can be applied in a method of treatment embolization, which is a method of treating opuholi.6. Microparticles according to claim. 1, characterized in that the drug is selected from the group consisting of antineoplastic medicines, anti-angiogenesis, anti-fungal drugs, antiviral drugs, antiinflammatory drugs, antimicrobial drugs, antihistamine drugs, antineoplastic drugs, enzymes, anti-allergenic drugs, and preferably represents anthracycline or camptothecin soedinenie.7. Microparticles according to claim. 1, characterized in that the microparticles are mikrosfery.8. Microparticles according to claim. 1, characterized in that the polymer is an acrylic polimer.9. Microparticles according to any of claims. 1-7, wherein the polymer is blamed1. Микрочастицы, содержащие гелевую структуру, которая содержит синтетический полимер и лекарство, где указанные микрочастицы имеют средний диаметр в диапазоне от 40 до 1500 мкм, а полимер является поперечно сшитым группами, содержащими дисульфидные связи, и находится в форме гидрогеля.2. Микрочастицы по п. 1 для применения в способе лечения эмболизацией, включающем этап высвобождения лекарства.3. Микрочастицы по п.
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