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New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
- 专利权人:
- INC.;ACHILLION PHARMACEUTICALS
- 发明人:
- PHADKE, AVINASH,CHEN, DAWEI,GADHACHANDA, VENKAT,HASHIMOTO, AKIHIRO,PAIS, GODWIN,WANG, XIANGZHU,AGARWAL, ATUL,KIM, HA YOUNG,LI, SHOUMING,LIU, CUIXIAN,ZHANG, SUOMING,DESHPANDE, MILIND
- 申请号：
- ES09832541
- 公开号：
- ES2527166T3
- 申请日:
- 2009.12.10
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound or pharmaceutically acceptable salt thereof, wherein the compound is: (2S, 4R) -1 - ((S) -2-tert-butyl-4-oxo-4- (piperidin-1-5 yl) butanoyl ) -N - ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2- vinylcyclopropyl) -4- (2- (pyridin-2-yl) -8,9-dihydrofuro [2,3-h] quinolin-4 -yloxy) pyrrolidin-2-carboxamide； (152) (2S, 4R) -1 - ((S) -2-tert-butyl-4-morpholino-4-oxobutanoyl) -N - ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2- vinylcyclopropyl) -4- (2- (pyridin-2-yl) -8,9-dihydrofuro [2,3-h] quinolin-4-yloxy) pyrrolidin-2-carboxamide； (153) (2S, 4R) -1 - ((S) -2-tert-butyl-4-oxo-4- (piperidin-1-yl) butanoyl) -N - ((1R, 2S) -1- ( cyclopropylsulfonylcarbamoyl) -2- vinylcyclopropyl) -4- (7-methoxy-2- (pyridin-2-yl) quinolin-4-yloxy) pyrrolidin-2-carboxamide； (165) (2S, 4R) -1 - ((S) -2-tert-butyl-4-oxo-4- (piperidin-1-yl) butanoyl) -4- (8-chloro-7-methoxy-2 - (pyridin-2-yl) quinolin-4-yloxy) -N- ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2-vinylcyclopropyl) pyrrolidin-2-carboxamide； (179) (2S, 4R) -1 - ((S) -2-tert-butyl-4-morpholino-4-oxobutanoyl) -4- (8-chloro-7-methoxy-2- (pyridin-2-yl ) quinolin-4-yloxy) -N- ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2-vinylcyclopropyl) pyrrolidin-2-carboxamide； (180) (2S, 4R) -1 - ((S) -2-tert-butyl-4- (3,3-difluoropiperidin-1-yl) -4-oxobutanoyl) -4- (8-chloro-7- methoxy-2- (pyridin-2-yl) quinolin-4- yloxy) -N - ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2-vinylcyclopropyl) pyrrolidin-2-carboxamide； (181) N - ((3R, 5S) -1 - ((S) -2-tert-butyl-4- (3,3-difluoropyrrolidin-1-yl) -4-oxobutanoyl) -5 - ((1R, 2S) -1- (cyclopropylsulfonylcarbamoyl) -2-vinylcyclopropylcarbamoyl) pyrrolidin-3-yl) -9H-carbazol-9-carboxamide； (183) (2S, 4R) -1 - ((S) -2-tert-butyl-4- (4,4-difluoropiperidin-1-yl) -4-oxobutanoyl) -4- (8-chloro-7- methoxy-2- (pyridin-2-yl) quinolin-4- yloxy) -N - ((1R) -1- (cyclopropylsulfonylcarbamoyl) -2-vinylcyclopropyl) pyrrolidin-2-carboxamide； (194) N - ((3R, 5S) -1 - ((S) -2-tert-butyl-4- (3,3-difluoropyrr
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
