An adjustable oral interface for adapting a user’s anatomy to deliver a vacuum generated by an oral negative-pressure therapy system is disclosed. The adjustable oral interface may include a shield to be situated between lips and front teeth, and a negative pressure deliverable part to be coupled with the shield, and a tube to be connected to a negative pressure generation source, wherein the negative pressure deliverable part is to be adjustable situated at the space between tongue and upper palate conformable to the contour of the upper palate, whereby the oral interface delivers negative pressure via the negative pressure delivery part to both front and back of the oral cavity to eliminate air space between the tongue and the upper palate.本發明提供一種適應患者口腔結構的可調整式口部介面，用以傳遞口腔負壓治療系統產生的負壓。本發明可調整式口部介面包含一擋板，供安置於使用者的唇部與門牙之間，及 一負壓傳遞部件，連結於該擋板，以及 一流體管件，流體連通於該負壓傳遞部件與一負壓產生源之間。該負壓傳遞部件用以可調整地置放於使用者的舌頭與上顎之間的空間，以順形於使用者的上顎輪廓，俾利於該口部介面透過該負壓傳遞部件傳遞負壓到口腔的前端與後端區域，以減少舌頭與上顎之間的空氣空間。
