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Membrane type-1 matrix metalloprotein inhibitors and uses thereof
专利权人:
Richard Beliveau;Carine Nyalendo;Denis Gingras
发明人:
Richard Beliveau,Denis Gingras,Carine Nyalendo
申请号:
US13139931
公开号:
US08853353B2
申请日:
2009.12.17
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.
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