Membrane type-1 matrix metalloprotein inhibitors and uses thereof

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专利权人:

Richard Beliveau;Carine Nyalendo;Denis Gingras

发明人:

Richard Beliveau,Denis Gingras,Carine Nyalendo

申请号：

US13139931

公开号：

US08853353B2

申请日:

2009.12.17

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.

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