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TRAITEMENT DU CANCER PAR BLOCAGE DE L'INTERACTION DE TIM-3 ET DE SON LIGAND
专利权人:
INC.;IMMUTICS
发明人:
SUN, DONGXU,WANG, YAN
申请号:
CA3070446
公开号:
CA3070446A1
申请日:
2018.07.24
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Provided herein are methods of activating immune response and/or treating cancer in a patient comprising administering to the patient a Gal3:TIM-3 inhibitor that interferes with the interaction between Gal3 and TIM-3, where said inhibitor is administered in an amount sufficient to activate immune response. Also provided are a humanized anti-Gal3 antibodies that can block the interaction between Gal3 and TIM3 and methods of using the anti-Gal3 antibody to treat cancer. Methods for determining if a patient's cancer is suitable for treatment with a Gal3:TIM-3 inhibitor and methods for selecting compounds that can block interaction between Gal3 and TIM-3, activating immune response and/or treating cancer are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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