Bonnie Bassler;Megan Eileen Bolitho;Martin Semmelhack;Douglas A. Higgins;Wai-Leung Ng;Kristina M. Kraml
发明人:
Bonnie Bassler,Martin Semmelhack,Douglas A. Higgins,Megan Eileen Bolitho,Kristina M. Kraml,Wai-Leung Ng
申请号：
US12681041
公开号：
US08535689B2
申请日:
2008.10.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
