Simona M. Ceccarelli,Ravi Jagasia,Roland Jakob-Roetne,Juergen Wichmann
申请号：
US14602541
公开号：
US09440962B2
申请日:
2015.01.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compounds of general formulawhereinAr1/Ar2 are phenyl or a 5 or 6-membered heteroaryl；R1/R2 is hydrogen, halogen, lower alkyl, CF3 or lower alkoxy；n,m are 1 or 2；or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof, with the exception of the compound 2,1-benzisoxazole, 3-(4-chlorophenyl)-5-(1-phenyl-1H-pyrazol-5 -yl)-.The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.
