Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
发明人:
Wu Zhong,Song Li,Shuang Cao,Ruiyuan Cao,Junhai Xiao,Xinbo Zhou,Xingzhou Li
申请号：
US15315226
公开号：
US10160767B2
申请日:
2015.06.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method, pharmaceutical composition and use thereof. The compounds of the present invention overcome the defects of rapamycin in terms of water solubility and metabolic properties, and some of the compounds have an in vitro anti-tumor activity superior to rapamycin, have less toxicity to normal cells than rapamycin, and have very good druggability.
