The present invention relates to cyclobenzaprine analogs and amitryptylene analogs, including deuterated forms useful for the treatment or prevention of symptoms associated with post-traumatic stress disorder. [Selection diagram] Fig. 2本発明は心的外傷後ストレス障害に関連する症状の治療又は予防に有用な重水素化形態を含むシクロベンザプリン類似体及びアミトリプチレン類似体に関する。【選択図】図2