1- [2- (2, 4-DIMETHYLPHENYLSULFANYL) -PHENYL] PIPERAZINE AS A COMPOUND WITH COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT
FALDT, ANDRE,MORK, ARNE,BANG-ANDERSEN, BENNY,LOPEZ DE DIEGO, HEIDI,HOLM, RENE,STENSBOL, TINE, BRYAN,RINGGAARD, LONE MUNCH,MEALY, MICHAEL J,ROCK, MICHAEL HAROLD,BRODERSEN, JORGEN,JORGENSEN, MORTEN,MOOR
申请号：
NZ57298607
公开号：
NZ572986A
申请日:
2007.06.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a crystalline form of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine and pharmaceutically acceptable salts thereof, particularly hydrobromide, hydrochloride, mesylate, fumerate, maleate, meso-tatrate, L-(+)-tatrate, D-(-)-tatrate, sulphate, phosphate or nitrate salts, compositions comprising said crystalline compound, processes for their preparation. Said compounds is useful in the treatment of affect affective disorders depression, major depressive disorder postnatal depression depression associated with bipolar disorder, Alzheimers disease, psychosis, cancer, age or Parkinsons disease anxiety general anxiety disorder social anxiety disorder obsessive compulsive disorder panic disorder panic attacks phobia social phobia agoraphobia stress urinary incontinence emesis IBS eating disorders chronic pain partial responders treatment resistant depression Alzheimers disease cognitive impairment ADHD melancholia PTSD hot flushes sleep apnea alcohol, nicotine or carbohydrate craving substance abuse or alcohol or drug abuse.
