605022 Provided are substituted triazolo-pyridine and substituted quinazolo-pyridine derivatives represented by the structural formulae shown herein and methods for producing them. The compounds are useful as selective Src tyrosine kinase inhibitors and are suitable for the treatment of disorders involving tyrosine kinase dysregulation such as disorders associated with increased vascular permeability or angiogenesis, in particular, cardiovascular diseases, diabetes, diabetes-associated disorders, inflammatory diseases, immunological disorders, cancer and eye diseases such as retinopathies, macular degeneration or other vitreoretinal diseases.
