PROBLEM TO BE SOLVED: To provide a collagen material covalently bound to particles, which results in a material that is more resistant to degradation such as collagenase degradation and that can be used in a wide range of applications.SOLUTION: Provided is an injectable or transplantable composition comprising collagen covalently bound to particles, wherein covalent amide bonds are formed between free carboxylic acid groups of the collagen and amine reactive groups of the particles, and wherein the particles have an average particle diameter size ranging from 20 to 1000 nanometers. Preferable is the composition wherein the particles have an average particle diameter between 50 and 150 nanometers. Also preferable is the composition wherein the collagen is cross-linked with a carbodiimide cross-linking agent, and the cross-linked collagen is porous and has an average pore size ranging from 500 nm to 200 μm or from 1 to 100 μm.SELECTED DRAWING: None【課題】コラゲナーゼ分解のような分解にいっそう耐性であり、広範囲の用途において用いることができる、粒子に共有結合されたコラーゲン材料の提供。【解決手段】粒子に共有結合されたコラーゲンを含む注射又は移植可能な組成物であって、コラーゲンの遊離カルボン酸基と粒子のアミン反応基との間で共有アミド結合が形成され、かつ粒子が、20～1000ｎｍに及ぶ平均粒径を有する、組成物。好ましくは、粒子が５０～１５０ナノメートルの平均粒径を有する、組成物。コラーゲンがカルボジイミド架橋剤で架橋されており、架橋されたコラーゲンが多孔性であり、かつ５００ｎｍ～２００μｍ又は１～１００μｍに及ぶ平均細孔サイズを有することが好ましい組成物。【選択図】なし
