The present invention relates to human insulin analogues and acidylated derivatives thereof. In particular, the present invention relates to human insulin analogues, acidylated derivatives, pharmaceutically acceptable salts, preparation processes thereof and applications thereof in medicine, and uses thereof as therapeutical agents, especially for Anti-Diabetic. The insulin analogues provided by present invention have improved pharmacodynamic properties and can be used to treat diabetes and can be used in glycemic control of alzheimer disease, ICU critical patients.本發明涉及人胰島素類似物及其醯化衍生物。具體而言,本發明涉及一種人胰島素類似物及其醯化衍生物、其生理耐受鹽、其製備方法及其在醫藥上的應用,以及它們作為治療劑特別是作為糖尿病治療劑的用途。本發明提供的胰島素衍生物具有改進的生物藥效的性質,可用於治療糖尿病以及阿茲海默症、ICU重症病人血糖控制。該代表圖無元件符號及其所代表之意義。
