TO, MICHAEL KAI TSUN,杜 启峻,杜 啟峻,LAU, JOHNSON YIU-NAM,刘 耀南,劉 耀南,CHEUNG, KENNETH MAN CHEE,张 文智,張 文智,杜 启峻,杜 啟峻,刘 耀南,劉 耀南,张 文智,張 文智
申请号：
TW107106007
公开号：
TW201834667A
申请日:
2018.02.22
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
A preparation of silver nanoparticles has been found to be effective in improving functional and behavioral recovery from traumatic spinal cord injury. The silver nanoparticles are provided in a non-flowable gel vehicle, from which they are release at high efficiency, that is applied locally at the site of the spinal cord injury. Silver nanoparticle formulations described herein were found to modify the M1/M2 macrophage phenotype ratio and provides a synergistic effect in the combination with arginase to promote healing processes at the treated injury site, reducing post-injury inflammation.一種銀奈米顆粒的製劑已被發現可以有效改善創傷性脊髓損傷的功能和行為恢復。銀奈米顆粒以非流動性凝膠載體所提供，且係從載體中高效率釋放，並被局部施用於脊髓損傷部位。本文發現銀奈米顆粒製劑會改變M1/M2巨噬細胞表型比(phenotype ratio)，且與精胺酸酶搭配施用會提供協同效應以促進在受治療的損傷部位的癒合過程，從而減少損傷後發炎。
