The Board of Trustees of the Leland Stanford Junior University
发明人:
Deisseroth, Karl A.,Tye, Kay M.,Warden, Melissa R.
申请号：
AU20130235517
公开号：
AU2013235517(B2)
申请日:
2013.03.13
申请国别(地区):
澳大利亚
年份:
2018
代理人:
摘要：
The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light- responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.
