The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.本發明係關於能與凝血因子XI及/或其活化型式XIa因子結合之抗體及其用途,特別是用作抑制血小板凝集及藉此抑制血栓形成之方法。