The invention relates to a compound of the 5-acylsulfanyl-histidine type and its derivatives corresponding to the following general formula (I): in which: R1 to R3 = H, alkyl, in particular CH3; R4 = H, alkyl, especially CH3, alkyl (C = O), substituted alkyl (C = O), aryl (C = O); The invention also relates to the use of this compound for preparing 5-sulfanyl-histidine-type compounds and its compounds, and to the use of this compound in the preparation of 5-sulfanyl-histidine compounds. derivatives, as well as corresponding disulfides, and their various methods of preparation. L'invention concerne un composé de type 5-acylsulf anyl-histidine et ses dérivés répondant à la formule générale (I) suivante : dans laquelle : R1 à R3 = H, alkyle, en particulier CH3 ; R4 = H, alkyle, en particulier CH3, alkyle (C=O), alkyle substitué (C=O), aryle(C=O) ; β-alanyle (H2NCH2CH2 (C=O) ; α-amino-acyle ; R5 = alkyle, en particulier méthyle, phényle. L'invention concerne aussi l'utilisation de ce composé pour préparer des composés type 5-sulfanyl-histidine et ses dérivés, ainsi que des disulfures correspondants ; et leurs divers procédés de préparation.