Provided are compositions that include one or more natural recombinant and/or modified allergens with a pharmaceutically acceptable non aqueous solvent to form an immunotherapy composition that includes the active ingredient and solvent wherein the immunotherapy compostion is formulated for administration to a subject in need of immunotherapy. The solvent is miscible with water and interstitial fluid. The at least one active ingredient is soluble in the solvent and insoluble in water and in an aqueous phase of the interstitial fluid. The present compositions may be administered to a subject for example as part of an immunotherapy regimen to help induce a state of immunologic tolerance to one or more allergies or as treatment for an autoimmune disease. Also provided are methods of making such compositions. Further provided are methods that include administering the composition to a mammal.
