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2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
专利权人:
Pawel Grzywacz;Hector F. DeLuca;Margaret Clagett-Dame;Lori A. Plum
发明人:
Hector F. DeLuca,Lori A. Plum,Margaret Clagett-Dame,Pawel Grzywacz
申请号:
US11697434
公开号:
US08404666B2
申请日:
2007.04.06
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Compounds of formula I, II or III are provided where X1, X2 and X3 are independently selected from H and hydroxy protecting groups and R1 and R2 are independently selected from H or straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms; and R3 is independently selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
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