The present invention relates to, inter alia, one or more first immunogenic polypeptides derived from Mycobacterium spp. for use in a method of raising an immune response against said Mycobacterium spp. wherein the one or more first immunogenic polypeptides are administered concomitantly with (i) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said Mycobacterium spp. and (ii) an adjuvant. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants.
