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BICYKLICZNY ZAWIERAJĄCY AZOT AROMATYCZNY HETEROCYKLICZNY ZWIĄZEK AMIDOWY
专利权人:
Astellas Pharma Inc.
发明人:
OHNUKI KEI,AZAMI HIDENORI,SAWADA YUKI,SHIN TAKASHI,KURAMOTO KAZUYUKI,KIKUCHI SHIGETOSHI,SAITO TOMOYUKI,HAMAGUCHI HISAO,NAGASHIMA TAKEYUKI
申请号:
PL14810281
公开号:
PL3009424T3
申请日:
2014.06.09
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
This invention relates to a bicyclic nitrogen-containing aromatic heterocyclic amide compound of formula (I), or a salt thereof, which has excellent Complex 1 inhibitory effect and AMPK activating effect, and which is useful as a therapeutic drug for breast cancer. This compound has a cell growth inhibitory effect on a human PIK3CA mutation-positive breast cancer cell line not expressing MCT4 and on a human breast cancer cell line not expressing MCT4 and not having a PIK3CA mutation, and exhibits antitumor action in human PIK3CA mutation-positive breast cancer cell line MDA-MB-453 cell tumor-bearing mice not expressing MCT4.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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