MOLÉCULE DE DÉLIVRANCE DE MÉDICAMENT SOUS FORME CYTOTOXIQUE CIBLANT LE VIH (CDM-H), ACTIVITÉ CYTOTOXIQUE CONTRE LE VIRUS DE L'IMMUNODÉFICIENCE HUMAINE ET LEURS MÉTHODES D'UTILISATION

• 收藏
• 分享

专利权人:

YALE UNIVERSITY

发明人:

SPIEGEL, DAVID,PARKER, CHRISTOPHER

申请号：

EP13780662

公开号：

EP2841107A4

申请日:

2013.03.15

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/