CARROLL, DAVID,SRAN, ARVINDER,SINGH, RAJINDER,HUANG, JIANING,TSVETKOV, LYUBEN,ISSAKANI, SARKIZ,PAYAN, DONALD,SHAW, SIMON
申请号：
CA2958142
公开号：
CA2958142A1
申请日:
2015.08.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure. Formule (I) and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors.
