For the purpose of preventing periodontal diseases and preventing and reducing unpleasant breath odors, it is very important to inhibit the proliferation of F. nucleatum and P. intermedia. These species of bacteria are known to cause coflocculation. Therefore, it can be expected that periodontal diseases and unpleasant breath odors caused by these species of bacteria would be prevented and reduced efficiently by inhibiting the coflocculation. Since these species of bacteria occur in the oral cavity, it is needed to inhibit the coflocculation by a method that is not harmful to human bodies. An inhibitor of the coflocculation of F. nucleatum and P. intermedia, which is characterized by comprising lactoferrin, can inhibit the coflocculation of these species of bacteria without causing harm to human bodies.有關謀求預防牙周病、預防及降低口臭方面，抑制核粒梭菌(F.nucleatum)與中間普雷沃菌(P.intermedia)的增殖具有相當大的意義。另外由於已知該等菌種會形成共凝集，藉由阻礙該共凝集，可期待有效率地預防及降低起因於該等菌種之牙周病及口臭。然而，由於該等菌種存在於口腔內，目前正尋求藉由對人體無害之方法來抑制該等菌種之共凝集。藉由特徵為含有乳鐵蛋白之核粒梭菌(F.nucleatum)與中間普雷沃菌(P.intermedia)之共凝集阻礙劑，對人體無害並可阻礙該等菌種之共凝集。
