A nasal cannula having a slide rail and a positioning mechanism, the nasal catheter having a soft nasal cannula body coupled to a rigid rail frame, the nasal catheter body forming a resilient portion on the slide rail frame, Each of the two sides of the slide rail frame has a first positioning portion and a track; a rigid intake pipe member has a pair of first convex portions and a pair of second positioning portions; wherein each of the first convex portions can be inserted into each track The first positioning portion and each of the second positioning portions are mutually positionable; the intake pipe member can quickly join the nasal conduit body in a sliding manner along a track direction of the sliding rail frame, and the intake pipe member can be along the The track direction of the rail frame quickly separates the nose catheter body in a sliding manner.一種具有滑軌與定位機構的鼻導管,該鼻導管具有一軟質的鼻導管體,該鼻導管體結合一硬質的滑軌框架,該鼻導管體於該滑軌框架上形成一彈性部,該滑軌框架的兩側邊各別具有一第一定位部及一軌道;一硬質的進氣管件具有一對第一凸部及一對第二定位部;其中各第一凸部可插入各軌道,各第一定位部與各第二定位部可相互定位;該進氣管件可沿著該滑軌框架的軌道方向以滑動方式快速地結合該鼻導管體,且該進氣管件可沿著該滑軌框架的軌道方向以滑動方式快速地分離該鼻導管體。