The United States of America; as represented by the Secretary; Dept. of Health and Human Services
发明人:
Yun-Xing Wang,Ping Yu
申请号：
US16664523
公开号：
US20200048310A1
申请日:
2019.10.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also disclosed are methods of treating or inhibiting HIV including administering one or more of the disclosed compounds to a subject.
