SYSTEMS AND METHODS FOR NASAL IRRIGATION ARE PROVIDED IN WHICH A NASAL IRRIGATION DEVICE INCLUDES A SOURCE OF SALINE SOLUTION, AN EFFLUENT RECEPTACLE (14), A NASAL INTERFACE, A VACUUM SOURCE, A FLUID PASSAGEWAY TO COMMUNICATE THE SOURCE OF SALINE SOLUTION WITH THE EFFLUENT RECEPTACLE (14) THROUGH THE NASAL INTERFACE (38) AND A NASAL CAVITY OF THE USER, AND A SWITCH (70) AND VALVE ASSEMBLY FOR SELECTIVELY CONTROLLING THE VACUUM SOURCE AND FLOW OF THE SALINE SOLUTION THROUGH THE FLUID PASSAGEWAY. THE SALINE SOLUTION SOURCE IS DISPOSED RELATIVE TO THE DEVICE TO PROVIDE GRAVITATIONAL INDUCEMENT OF SALINE SOLUTION TO THE NASAL INTERFACE (38) IN ENGAGEMENT TO THE DEVICE USER'S NOSTRILS. A COMBINATION OF THE GRAVITATIONAL INDUCEMENT AND THE RELATIVE VACUUM FROM THE EFFLUENT RECEPTACLE (14) GENERATES A FLUID FLOW FOR IRRIGATING, CLEANSING AND MASSAGING THE NASAL CAVITY AND OSTIA OF A USER. THE ENTIRE DEVICE IS ASSEMBLED AS A HAND-HELD DEVICE FOR CONVENIENT LIFTING AND DISPOSAL AGAINST THE USER'S NOSTRILS.