Described are compositions of matter and methods useful for increasing the yield of transgenic agricultural crops. Sequence information of ENOX proteins and methods for transfection are disclosed. Additionally, small molecule activators of ENOX proteins are disclosed. Sequence information from ENOX proteins from the yeast Saccharomyces cerevisiae, Aribidopsis thaliana and Prunus persicaria are disclosed. Transgenic microorganisms and/or plants are disclosed which may express one or more of the follow characteristics including, but not limited to, accelerated maturity, increased cell size, increased standability, increased root and xylem development, and increased yield.