STEWART, ROSS ANTHONY,TIGUE, NATALIE JO,YOUNG, LESLEY LYNN,HIGAZI, DANIEL RAMSAY,BAMBER, LISA,SRIDHARAN, SUDHARSAN,LEYLAND, REBECCA,DURHAM, NICHOLAS MASON
申请号：
CA2994346
公开号：
CA2994346A1
申请日:
2016.08.11
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
