The compound of formula (I) is provided R wherein 2, R 3, R 13, L and D 2As the definition in the specification sheets, described compound can maybe can be by activating disease or the illness that glucokinase is treated by glucokinase activity level defective mediation with treating and/or preventing, and described disease or illness include but not limited to that diabetes, glucose tolerance reduce, IFG (fasting glucose is impaired) and IFG (impaired fasting glucose (IFG)) and other those diseases and illness as discussing below.