Dae-Yoon Chi,Byoung-Se Lee,Chansoo Park,Min-Hyung Lee,Hyojin Cha,Woojin Cho,Heewon Kang,Kyunghun Kim
申请号：
US14117271
公开号：
US09505799B2
申请日:
2012.05.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.
