SEX STEROID PRECURSORS ALONE OR IN COMBINATION WITH A SELECTIVE ESTROGEN RECEPTOR MODULATOR AND/OR WITH ESTROGENS AND/OR A TYPE 5 CGMP PHOSPHODIESTERASE INHIBITOR FOR THE PREVENTION AND TREATMENT OF VAGINAL DRYNESS AND SEXUAL DYSFUNCTION IN POSTMENOPAUSAL WOMEN
SEXUAL STEROID PRECURSORS ISOLATED OR IN COMBINATION WITH A SELECTIVE STROGEN RECEIVER MODULATOR AND / OR WITH CGMP STROGEN AND / OR TYPE 5 PHOSPHODIESTERASE INHIBITOR FOR THE PREVENTION AND TREATMENT OF VAGINAL DRY AND PERSONAL MUSPULAR DISFUSION. New methods for treating or reducing the likelihood of acquiring vaginal dysfunction, more particularly vaginal dryness and dyspareunia, leading to sexual dysfunction and low sexual desire and performance, in susceptible warm-blooded animals including humans involving the administration of a sex steroid precursor. . Additional administration of estrogen or selective estrogen receptor modulator, particularly those selected from the group consisting of Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923, and Lasofoxifene, and more particularly compounds that are have the general structure are specifically disclosed for the medical treatment and / or inhibition of the development of some of the aforementioned diseases. Pharmaceutical compositions for delivery of active ingredient (s) and kit (s) useful for the invention are also disclosed.Opisane su nove metode za tretiranje ili smanjenje vjerojatnosti pojave vaginalnih disfunkcija, konkretno vaginalne suhoće i dispareunije, što dovodi do seksualne disfunkcije i slabe seksualne želje i sposobnosti, u osjetljivih toplokrvnih životinja i ljudi, koje uključuju primjenu spolnog steroidnog prekursora. Zatim, specifično je opisana primjena estrogenskog ili selektivnog estrogenskog receptorskog modulatora, konkretno onih koji su odabrani iz skupa kojega sačinjavaju Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923 i lazofoksifen, te konkretnije spojevi koji su opće formule:<；BR/>；<；IMAGE NAME="20070169_01" TYPE="jpg" CENTER=TRUE/>；<；BR/>； nza medicinski tretman i/ili inhibiranje razvoja nekih od gore navedenih bolesti. Također su opisane farmaceutske smjese za unošenje aktivnih
