The present invention relates to substituted imidazo[4,5-c]quinoline derivatives of formula (I), wherein R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of the present invention and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammation and angiogenesis related disorders.本発明は、式(I)(式中、R1、R2およびR3は本明細書で定義される通りである)の置換イミダゾ[4,5-c]キノリン誘導体、その製造方法、本発明の化合物を含む医薬組成物、および1つ以上のキナーゼが介在する疾患または障害、特に癌などの増殖性疾患または障害の治療へのそれらの使用に関する。炎症および血管新生関連障害の治療にも、これらの化合物を用いることができる。