Thomas Arrhenius,Jie Fei Cheng,Mark E. Wilson,Rossy Serafimov,Alex M. Nadzan,Gary D. Lopaschuk,Jason R. Dyck
申请号：
US12772552
公开号：
US08110686B2
申请日:
2010.05.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
