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Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor
专利权人:
Kotaro Gotanda;Kenji Kawade;Youichi Nakano;Atsushi Shinbo;Shuichiro Sato;Makoto Okada;Hideo Kobayashi
发明人:
Makoto Okada,Shuichiro Sato,Kenji Kawade,Kotaro Gotanda,Atsushi Shinbo,Youichi Nakano,Hideo Kobayashi
申请号:
US12448212
公开号:
US08299080B2
申请日:
2007.12.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I)in the formula,R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.
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