Ben WEN,Anthony E. BOITANO,Matthew BURGER,Susan E. CELLITTI,Michael P. COOKE,Catrin FINNER,Bernhard Hubert GEIERSTANGER,Yunho JIN,Si Tuen LEE-HOEFLICH,HongNgoc Thi PHAM,Siew Ho SCHLEYER,Kathrin TISSOT
申请号：
US16470897
公开号：
US20190321483A1
申请日:
2017.12.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates； and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
