compound, pharmaceutical composition, and methods for treating disease or disorder, for inhibiting binding of chemokines to a receptor, for imaging an said tumor, organ or tissue, and for detecting elevated levels of cxcr7 in a sample.
JAY POWERS,JEFFREY P. MCMAHON,JUAN C. JAEN,LIANFA LI,MARK M. GLEASON,PENGLIE ZHANG,PINGCHEN FAN,XI CHEN,YIBIN ZENG
申请号：
BRPI0921496
公开号：
BRPI0921496A2
申请日:
2009.11.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
