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SORAFENIB HEMI-P-TOSYLATE MONOHYDRATE CRYSTAL AND PREPARATION PROCESS THEREOF
专利权人:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LTD.
发明人:
Shufeng WU,Aiming ZHANG,Xiquan ZHANG,Xueyan ZHU
申请号:
US16062030
公开号:
US20180370918A1
申请日:
2016.09.23
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to the field of medicinal technology, and in particular, to sorafenib hemi-p-tosylate monohydrate crystal and preparation process thereof. The crystal has diffraction peaks occurring at 2θ angle of about 5.62, 6.67, 8.05, 9.06, 9.63, 9.91, 10.95, 11.25, 13.48, 14.00, 14.60, 15.08, 15.75, 16.20, 16.62, 16.80, 17.23, 18.40, 18.97, 19.32, 19.82, 20.49, 20.74, 21.51, 22.56, 22.86, 23.37, 23.71, 24.20, 24.71, 24.97, 25.54, 25.80, 26.18, 27.14, 27.48, and 28.29 degree in a X-ray powder diffraction pattern, and some advantages, such as a high stability, a low hygroscopicity and the like.
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