University of Connecticut;Carnegie Mellon University
发明人:
Anne M. Arnold,Brian D. Holt,Stefanie A. Sydlik,Cato T. Laurencin,Leila Daneshmandi
申请号：
US16610814
公开号：
US20200069838A1
申请日:
2018.05.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method for functionalizing graphene oxide includes reacting graphene oxide with a phosphite compound and a metal salt in the presence of a Lewis acid to produce phosphate functionalized graphene oxide including ions of the metal. An apparatus includes a bone scaffold construct formed of phosphate functionalized graphene oxide including metal ions. A bone scaffold construct includes a graphene oxide material formed in the shape of the bone scaffold construct, the graphene oxide material including graphene oxide, phosphate moieties covalently bound to the graphene oxide, and metal counter ions chemically associated with the phosphate moieties. A method for treating a bone defect includes administering a therapeutically effective amount of phosphate functionalized graphene oxide including metal ions.
