Soluble PDL-1 molecules with high affinity

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专利权人:

グアンジョウ;インスティテュート;オブ;バイオメディスン;アンド;ヘルス，チャイニーズ;アカデミー;オブ;サイエンスィズ

发明人:

リ，イー,リアン，チャオドュアン

申请号：

JP2018518441

公开号：

JP6650515B2

申请日:

2016.10.09

申请国别(地区):

JP

年份:

2020

代理人:

摘要：

The present invention provides a PDL-1 molecule wherein the affinity of the PDL-1 molecule and the PD-1 molecule is at least twice the affinity of the wild-type PDL-1 molecule and the PD-1 molecule. At the same time, the PDL-1 molecule of the present invention can effectively improve the killing ability of lymphocytes. Furthermore, the present invention provides a nucleic acid encoding the PDL-1 molecule of the invention and a complex of the PDL-1 molecule of the invention. The PDL-1 molecule of the present invention may be used alone or in combination with other molecules.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/